Buy Jalyn, Duodart, Urimax-D (Dutasteride with Tamsulosin) online

Buy Jalyn, Duodart, Urimax-D (Dutasteride and Tamsulosin) to treat BPH in men
Cheap qualitative Dutasteride with Tamsulosin HCl 0.5 mg / 0.4 mg pills online



HOW AND WHERE TO BUY URIMAX-D, DUODART, JALYN (DUTASTERIDE WITH TAMSULOSIN) 0.5 MG / 0.4 MG TABLETS OR CAPSULES ONLINE:

JALYN (DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE): PHARMACOKINETICS IN SPECIFIC POPULATIONS

Pediatric

The pharmacokinetics of dutasteride and tamsulosin administered together have not been investigated in subjects younger than 18 years.

Geriatric

Dutasteride and tamsulosin pharmacokinetics using Jalyn (Dutasteride, Tamsulosin Hydrochloride) capsules have not been studied in geriatric patients. The following text reflects information for the individual components.

Dutasteride

No dosage adjustment is necessary in the elderly. The pharmacokinetics and pharmacodynamics of dutasteride were evaluated in 36 healthy male subjects aged between 24 and 87 years following administration of a single 5-mg dose of dutasteride. In this single-dose study, dutasteride half-life increased with age (approximately 170 hours in men aged 20 to 49 years, approximately 260 hours in men aged 50 to 69 years, and approximately 300 hours in men older than 70 years).

Tamsulosin

Cross-study comparison of tamsulosin overall exposure (AUC) and half-life indicate that the pharmacokinetic disposition of tamsulosin may be slightly prolonged in geriatric males compared to young, healthy male volunteers. Intrinsic clearance is independent of tamsulosin binding to AAG, but diminishes with age, resulting in a 40% overall higher exposure (AUC) in subjects aged 55 to 75 years compared to subjects aged 20 to 32 years.

Gender

Dutasteride

Dutasteride is contraindicated in pregnancy and women of childbearing potential and is not indicated for use in other women. The pharmacokinetics of dutasteride in women have not been studied.

Tamsulosin

Tamsulosin is not indicated for use in women. No information is available on the pharmacokinetics of tamsulosin in women.

Race

The effect of race on pharmacokinetics of dutasteride and tamsulosin administered together or separately has not been studied.

Renal Impairment

The effect of renal impairment on dutasteride and tamsulosin pharmacokinetics has not been studied using Jalyn (Dutasteride and Tamsulosin). The following text reflects information for the individual components.

Dutasteride

The effect of renal impairment on dutasteride pharmacokinetics has not been studied. However, less than 0.1% of a steady-state 0.5-mg dose of dutasteride is recovered in human urine, so no adjustment in dosage is anticipated for patients with renal impairment.

Tamsulosin

The pharmacokinetics of tamsulosin have been compared in 6 subjects with mild-moderate (30 <= CLcr < 70 mL/min/1.73 m2) or moderate-severe (10 <= CLcr 659 < 30 mL/min/1.73 m2) renal impairment and 6 normal subjects (CLcr > 90 mL/min/1.73 m2). While a change in the overall plasma concentration of tamsulosin was observed as the result of altered binding to AAG, the unbound (active) concentration of tamsulosin, as well as the intrinsic clearance, remained relatively constant. Therefore, patients with renal impairment do not require an adjustment in tamsulosin dosing. However, patients with end-stage renal disease (CLcr < 10 mL/min/1.73 m2) have not been studied.

Hepatic Impairment

The effect of hepatic impairment on dutasteride and tamsulosin pharmacokinetics has not been studied using Jalyn (Dutasteride and Tamsulosin HCl). The following text reflects information available for the individual components.

Dutasteride

The effect of hepatic impairment on dutasteride pharmacokinetics has not been studied. Because dutasteride is extensively metabolized, exposure could be higher in hepatically impaired patients.

Tamsulosin

The pharmacokinetics of tamsulosin have been compared in 8 subjects with moderate hepatic impairment (Child-Pugh classification: Grades A and B) and 8 normal subjects. While a change in the overall plasma concentration of tamsulosin was observed as the result of altered binding to AAG, the unbound (active) concentration of tamsulosin does not change significantly with only a modest (32%) change in intrinsic clearance of unbound tamsulosin. Therefore, patients with moderate hepatic impairment do not require an adjustment in tamsulosin dosage. Tamsulosin has not been studied in patients with severe hepatic impairment.


Jalyn (Dutasteride, Tamsulosin) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Proscar medication guide - Finasteride
  • Tablets, Film-Coated; Oral; Finasteride 1 mg
  • Tablets, Film-Coated; Oral; Finasteride 5 mg
  • Merck
  • Menarini
  • Bicalutamida DOSA - Bicalutamide
  • Tablets, Film-Coated; Oral; Bicalutamide 50 mg
  • DOSA Laboratorio


  • Recent posts:

  • Buy Jalyn (Dutasteride, Tamsulosin HCl) Online
  • Jalyn prescribing information

    Copyright © Buy Duodart, Jalyn, Urimax-D (Dutasteride with Tamsulosin) Online