Buy Jalyn, Duodart, Urimax-D (Dutasteride with Tamsulosin) online

Buy Jalyn, Duodart, Urimax-D (Dutasteride and Tamsulosin) to treat BPH in men
Cheap qualitative Dutasteride with Tamsulosin HCl 0.5 mg / 0.4 mg pills online



HOW AND WHERE TO BUY URIMAX-D, DUODART, JALYN (DUTASTERIDE WITH TAMSULOSIN) 0.5 MG / 0.4 MG TABLETS OR CAPSULES ONLINE:

JALYN (DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE): DRUG INTERACTIONS

There have been no drug interaction studies using Jalyn (Dutasteride with Tamsulosin HCl) capsules. The following sections reflect information available for the individual components.

Cytochrome P450 3A Inhibitors

Dutasteride

Dutasteride is extensively metabolized in humans by the CYP3A4 and CYP3A5 isoenzymes. The effect of potent CYP3A4 inhibitors on dutasteride has not been studied. Because of the potential for drug-drug interactions, use caution when prescribing a dutasteride-containing product, including Dutasteride, Tamsulosin (Jalyn), to patients taking potent, chronic CYP3A4 enzyme inhibitors (e.g., ritonavir).

Tamsulosin

Strong and Moderate Inhibitors of CYP3A4 or CYP2D6

Tamsulosin is extensively metabolized, mainly by CYP3A4 or CYP2D6.

Concomitant treatment with ketoconazole (a strong inhibitor of CYP3A4) resulted in increases in the Cmax and AUC of tamsulosin by factors of 2.2 and 2.8, respectively. Concomitant treatment with paroxetine (a strong inhibitor of CYP2D6) resulted in increases in the Cmax and AUC of tamsulosin by factors of 1.3 and 1.6, respectively. A similar increase in exposure is expected in poor metabolizers (PM) of CYP2D6 as compared to extensive metabolizers (EM). Since CYP2D6 PMs cannot be readily identified and the potential for significant increase in tamsulosin exposure exists when tamsulosin 0.4 mg is coadministered with strong CYP3A4 inhibitors in CYP2D6 PMs, tamsulosin 0.4 mg capsules should not be used in combination with strong inhibitors of CYP3A4 (e.g., ketoconazole). The effects of coadministration of both a CYP3A4 and a CYP2D6 inhibitor with tamsulosin have not been evaluated. However, there is a potential for significant increase in tamsulosin exposure when tamsulosin 0.4 mg is coadministered with a combination of both CYP3A4 and CYP2D6 inhibitors.

Cimetidine

Treatment with cimetidine resulted in a moderate increase in tamsulosin hydrochloride AUC (44%).

Warfarin

Dutasteride

Concomitant administration of dutasteride 0.5 mg/day for 3 weeks with warfarin does not alter the steady-state pharmacokinetics of the S- or R-Warfarin isomers or alter the effect of warfarin on prothrombin time.

Tamsulosin

A definitive drug-drug interaction study between tamsulosin hydrochloride and warfarin was not conducted. Results from limited in vitro and in vivo studies are inconclusive. Caution should be exercised with concomitant administration of warfarin and tamsulosin-containing products, including Dutasteride, Tamsulosin HCl (Jalyn).

Nifedipine, Atenolol, Enalapril

Tamsulosin

Dosage adjustments are not necessary when tamsulosin is administered concomitantly with nifedipine, atenolol, or enalapril.

Digoxin and Theophylline

Dutasteride

Dutasteride does not alter the steady-state pharmacokinetics of digoxin when administered concomitantly at a dose of 0.5 mg/day for 3 weeks.

Tamsulosin

Dosage adjustments are not necessary when tamsulosin is administered concomitantly with digoxin or theophylline.

Furosemide

Tamsulosin

Tamsulosin had no effect on the pharmacodynamics (excretion of electrolytes) of furosemide. While furosemide produced an 11% to 12% reduction in tamsulosin hydrochloride Cmax and AUC, these changes are expected to be clinically insignificant and do not require adjustment of the dose of tamsulosin.

Calcium Channel Antagonists

Dutasteride

Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride. The change in dutasteride exposure is not considered to be clinically significant. No dosage adjustment of dutasteride is recommended.

Cholestyramine

Dutasteride

Administration of a single 5-mg dose of dutasteride followed 1 hour later by a 12-g dose of cholestyramine does not affect the relative bioavailability of dutasteride.


Jalyn (Dutasteride, Tamsulosin) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Cialis drug interactions - Tadalafil
  • Tablets, Film-Coated; Oral; Tadalafil 10 mg
  • Eli Lilly
  • DKSH


  • Recent posts:

  • Buy Jalyn (Dutasteride, Tamsulosin HCl) Online
  • Jalyn prescribing information

    Copyright © Buy Duodart, Jalyn, Urimax-D (Dutasteride with Tamsulosin) Online