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JALYN (DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE): CLINICAL PHARMACOLOGY

Mechanism of Action

Jalyn is a combination of 2 drugs with different mechanisms of action to improve symptoms in patients with BPH: dutasteride, a 5 alpha-reductase inhibitor, and tamsulosin, an antagonist of Alpha-1A-adrenoreceptors.

Dutasteride

Dutasteride inhibits the conversion of testosterone to dihydrotestosterone (DHT). DHT is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to DHT by the enzyme 5-alpha-reductase, which exists as 2 isoforms, type 1 and type 2. The type 2 isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also responsible for testosterone conversion in the skin and liver. Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human androgen receptor.

Tamsulosin

Smooth muscle tone is mediated by the sympathetic nervous stimulation of alpha1-adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck. Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and a reduction in symptoms of BPH.

Tamsulosin, an alpha1-adrenoceptor blocking agent, exhibits selectivity for alpha1-receptors in the human prostate. At least 3 discrete alpha1-adrenoceptor subtypes have been identified: alpha1A, alpha1B, and alpha1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha1A subtype. Tamsulosin is not intended for use as an antihypertensive.


Jalyn (Dutasteride, Tamsulosin) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Propecia clinical pharmacology - Finasteride
  • Tablets, Film-Coated; Oral; Finasteride 1 mg
  • Merck
  • Amimed Direct
  • Cialis clinical pharmacology - Tadalafil
  • Tablets, Film-Coated; Oral; Tadalafil 2.5 mg
  • Tablets, Film-Coated; Oral; Tadalafil 5 mg
  • Tablets, Film-Coated; Oral; Tadalafil 10 mg
  • Eli Lilly
  • Y.C. Woo


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