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DUODART (DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE): OVERDOSAGE

No data are available with regard to overdosage of Duodart (Dutasteride, Tamsulosin Hydrochloride). The following statements reflect the information available on the individual components.

Dutasteride

In volunteer studies single doses of dutasteride up to 40 mg/day (80 times the therapeutic dose) for 7 days have been administered without significant safety concerns. In clinical studies doses of 5 mg daily have been administered to patients for 6 months with no additional adverse effects to those seen at therapeutic doses of 0.5 mg.

There is no specific antidote for dutasteride therefore, in cases of suspected overdosage symptomatic and supportive treatment should be given as appropriate.

Contact a local poisons information centre for advice on overdose management.

Tamsulosin

In case of acute hypotension occurring after overdosage with tamsulosin hydrochloride cardiovascular support should be given. Restoration of blood pressure and normalization of heart rate may be accomplished by lying the patient down. If this is inadequate, administration of volume expanders and if necessary vasopressors should then be used and renal function should be monitored and supported as needed. Laboratory data indicate that tamsulosin hydrochloride is 94% to 99% protein bound; therefore, dialysis is unlikely to be of benefit in removing tamsulosin from the body.


Duodart (Dutasteride, Tamsulosin) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Minipress dosage and administration - Prazosin Hydrochloride
  • Capsules; Oral; Prazosin Hydrochloride 5 mg
  • Pfizer
  • Dexo Laboratoire
  • Bicalutamid Medac - Bicalutamide
  • Tablets, Film-Coated; Oral; Bicalutamide 50 mg
  • Tablets, Film-Coated; Oral; Bicalutamide 150 mg
  • Medac


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